4JMH

Crystal structure of synthetic protein in complex with double pY peptide

Summary for 4JMH

Related4JMG
DescriptorClamp Shc1_pY239/240, SHC-transforming protein 1 (3 entities in total)
Functional Keywordssynthetic protein, binding to double py containing sequence, de novo protein
Biological sourcesynthetic construct
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Cellular locationCytoplasm. Isoform p46Shc: Mitochondrion matrix. Isoform p66Shc: Mitochondrion (By similarity) P29353
Total number of polymer chains2
Total molecular weight24073.55
Authors
Yasui, N.,Smith, L.,Koide, S. (deposition date: 2013-03-14, release date: 2014-04-23, Last modification date: 2014-08-06)
Primary citation
Yasui, N.,Findlay, G.M.,Gish, G.D.,Hsiung, M.S.,Huang, J.,Tucholska, M.,Taylor, L.,Smith, L.,Boldridge, W.C.,Koide, A.,Pawson, T.,Koide, S.
Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.
Mol.Cell, 54:1034-1041, 2014
PubMed: 24910098 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2014.05.002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.408 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2777 0.5% 4.7% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02