4JKT

Crystal structure of mouse Glutaminase C, BPTES-bound form

Summary for 4JKT

Entry DOI	10.2210/pdb4jkt/pdb
Related	3SS3 3SS4 3SS5
Descriptor	Glutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide) (3 entities in total)
Functional Keywords	glutaminase, hydrolase
Biological source	Mus musculus (mouse)
Cellular location	Isoform 1: Cytoplasm, cytosol . Isoform 2: Mitochondrion: D3Z7P3
Total number of polymer chains	4
Total formula weight	214357.21
Authors	Fornezari, C.,Ferreira, A.P.S.,Dias, S.M.G.,Ambrosio, A.L.B. (deposition date: 2013-03-11, release date: 2013-08-14, Last modification date: 2023-09-20)
Primary citation	Ferreira, A.P.,Cassago, A.,Goncalves Kde, A.,Dias, M.M.,Adamoski, D.,Ascencao, C.F.,Honorato, R.V.,de Oliveira, J.F.,Ferreira, I.M.,Fornezari, C.,Bettini, J.,Oliveira, P.S.,Paes Leme, A.F.,Portugal, R.V.,Ambrosio, A.L.,Dias, S.M. Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor. J.Biol.Chem., 288:28009-28020, 2013 Cited by PubMed: 23935106 DOI: 10.1074/jbc.M113.501346 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation