4JKT

Crystal structure of mouse Glutaminase C, BPTES-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0006541	biological_process	glutamine metabolic process
B	0004359	molecular_function	glutaminase activity
B	0006541	biological_process	glutamine metabolic process
C	0004359	molecular_function	glutaminase activity
C	0006541	biological_process	glutamine metabolic process
D	0004359	molecular_function	glutaminase activity
D	0006541	biological_process	glutamine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 04A B 701

Chain	Residue
B	ARG322
C	LEU326
C	PHE327
C	LEU328
C	ASN329
C	TYR399
B	LYS325
B	LEU326
B	PHE327
B	LEU328
B	ASN329
B	GLU330
B	TYR399
C	LYS325

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 04A D 701

Chain	Residue
A	ARG322
A	LYS325
A	LEU326
A	PHE327
A	LEU328
A	ASN329
A	GLU330
A	TYR399
C	ARG322
D	ARG322
D	LYS325
D	PHE327
D	LEU328
D	ASN329
D	GLU330
D	TYR399

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:22228304, ECO:0007744|PDB:3SS5

Chain	Residue	Details
A	SER291
B	GLU386
B	ASN393
B	TYR419
B	TYR471
B	VAL489
C	SER291
C	ASN340
C	GLU386
C	ASN393
C	TYR419
A	ASN340
C	TYR471
C	VAL489
D	SER291
D	ASN340
D	GLU386
D	ASN393
D	TYR419
D	TYR471
D	VAL489
A	GLU386
A	ASN393
A	TYR419
A	TYR471
A	VAL489
B	SER291
B	ASN340

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site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS135
A	LYS169
B	LYS135
B	LYS169
C	LYS135
C	LYS169
D	LYS135
D	LYS169

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O94925

Chain	Residue	Details
A	LYS316
B	LYS316
C	LYS316
D	LYS316

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