4JKI

Crystal Structure of N10-Formyltetrahydrofolate Synthetase with ZD9331, Formylphosphate, and ADP

Replaces:  3SIN

Summary for 4JKI

• Entry DOI: 10.2210/pdb4jki/pdb
• Related: 3PZX 3RBO 3SIN 4JIM 4JJK 4JJZ
• Descriptor: Formate--tetrahydrofolate ligase, 2,7-dimethyl-6-[(prop-1-yn-1-ylamino)methyl]quinazolin-4(3H)-one, formyl phosphate, ... (6 entities in total)
• Functional Keywords: ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Moorella thermoacetica
• Total number of polymer chains: 2
• Total formula weight: 121202.71

Authors

Celeste, L.R.,Lovelace, L.L.,Lebioda, L. (deposition date: 2013-03-09, release date: 2013-03-20, Last modification date: 2023-09-20)

• Primary citation: Celeste, L.R.,Chai, G.,Bielak, M.,Minor, W.,Lovelace, L.L.,Lebioda, L.; Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.; Protein Sci., 21:219-228, 2012; PubMed: 22109967; DOI: 10.1002/pro.2005

Experimental method

X-RAY DIFFRACTION (2.6 Å)