4JK5
Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser)
Summary for 4JK5
Entry DOI | 10.2210/pdb4jk5/pdb |
Related | 3QN7 4GLY |
Related PRD ID | PRD_000926 |
Descriptor | Urokinase-type plasminogen activator, bicyclic peptide UK18-D-Ser, uPA inhibitor, SULFATE ION, ... (7 entities in total) |
Functional Keywords | serine protease, chymotrypsin fold, urokinase-type plasminogen activator, bicyclic peptide inhibitor, d-amino acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 30501.82 |
Authors | Buth, S.A.,Leiman, P.G.,Chen, S.,Heinis, C. (deposition date: 2013-03-09, release date: 2013-07-17, Last modification date: 2023-09-20) |
Primary citation | Chen, S.,Gfeller, D.,Buth, S.A.,Michielin, O.,Leiman, P.G.,Heinis, C. Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids. Chembiochem, 14:1316-1322, 2013 Cited by PubMed: 23828687DOI: 10.1002/cbic.201300228 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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