4JK5
Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 245 | 27586.4 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
| 2 | B (B) | bicyclic peptide UK18-D-Ser, uPA inhibitor | polymer | 18 | 1821.0 | 1 | BIRD (PRD_000926) | Synthetic construct | |
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I (A) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 6 | J (B) | 1,3,5-tris(bromomethyl)benzene | non-polymer | 356.9 | 1 | BIRD (PRD_000926) Chemie (ZBR) | |||
| 7 | K, L (A, B) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A: 16 - 242 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29407.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1094.4 | |
| All* | Total formula weight | 30501.8 |
