4JII

Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat

Summary for 4JII

• Entry DOI: 10.2210/pdb4jii/pdb
• Related: 4GQ0 4GQG 4I5X 4JIH 4JIR
• Descriptor: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (5 entities in total)
• Functional Keywords: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome : O60218
• Total number of polymer chains: 1
• Total formula weight: 37483.53

Authors

Zhang, L.,Zheng, X.,Zhang, H.,Zhao, Y.,Chen, K.,Zhai, J.,Hu, X.,Structural Genomics Consortium (SGC) (deposition date: 2013-03-06, release date: 2013-10-23, Last modification date: 2023-09-20)

• Primary citation: Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X.; Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).; Febs Lett., 587:3681-3686, 2013; PubMed: 24100137; DOI: 10.1016/j.febslet.2013.09.031

Experimental method

X-RAY DIFFRACTION (2.2 Å)