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4JIH

Crystal Structure Of AKR1B10 Complexed With NADP+ And Epalrestat

Summary for 4JIH
Entry DOI10.2210/pdb4jih/pdb
Related4GQ0 4GQG 4I5X 4JII 4JIR
DescriptorAldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordstim barrel, oxidoreductases, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationLysosome : O60218
Total number of polymer chains1
Total formula weight37376.56
Authors
Zhang, L.,Zheng, X.,Zhang, H.,Zhao, Y.,Chen, K.,Zhai, J.,Hu, X.,Structural Genomics Consortium (SGC) (deposition date: 2013-03-06, release date: 2013-10-23, Last modification date: 2023-12-06)
Primary citationZhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X.
Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587:3681-3686, 2013
Cited by
PubMed: 24100137
DOI: 10.1016/j.febslet.2013.09.031
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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