4JIH
Crystal Structure Of AKR1B10 Complexed With NADP+ And Epalrestat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldo-keto reductase family 1 member B10 | polymer | 318 | 36313.8 | 1 | UniProt (O60218) Pfam (PF00248) | Homo sapiens (human) | ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase |
| 2 | B (A) | {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid | non-polymer | 319.4 | 1 | Chemie (EPR) | |||
| 3 | C (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 4 | D (A) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A: 1 - 316 (UniProt: O60218)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Asp 313 | Asn 313 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36313.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1062.8 | |
| All* | Total formula weight | 37376.6 |
