4JIH
Crystal Structure Of AKR1B10 Complexed With NADP+ And Epalrestat
Summary for 4JIH
Entry DOI | 10.2210/pdb4jih/pdb |
Related | 4GQ0 4GQG 4I5X 4JII 4JIR |
Descriptor | Aldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductases, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37376.56 |
Authors | |
Primary citation | Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). Febs Lett., 587:3681-3686, 2013 Cited by PubMed: 24100137DOI: 10.1016/j.febslet.2013.09.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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