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4JFN

Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper

Summary for 4JFN
Entry DOI10.2210/pdb4jfn/pdb
DescriptorAmyloid beta A4 protein, COPPER (II) ION, GLYCEROL, ... (4 entities in total)
Functional Keywordsalzheimer's disease, gfld, app, growth factor-like domain, copper binding, metal binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P05067
Total number of polymer chains1
Total formula weight18776.02
Authors
Wild, K.,Baumkotter, F.,Kins, S. (deposition date: 2013-02-28, release date: 2014-07-23, Last modification date: 2023-11-08)
Primary citationBaumkotter, F.,Schmidt, N.,Vargas, C.,Schilling, S.,Weber, R.,Wagner, K.,Fiedler, S.,Klug, W.,Radzimanowski, J.,Nickolaus, S.,Keller, S.,Eggert, S.,Wild, K.,Kins, S.
Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain
J.Neurosci., 34:11159-11172, 2014
Cited by
PubMed: 25122912
DOI: 10.1523/JNEUROSCI.0180-14.2014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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