4JFN

Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008201	molecular_function	heparin binding
A	0016020	cellular_component	membrane
A	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 201

Chain	Residue
A	ASP23
A	ARG40
A	HIS108
A	HIS110

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	VAL76
A	TYR77
A	GLN90
A	HOH327
A	HIS44
A	MET45
A	ASN46
A	VAL47
A	ASP53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:8158260

Chain	Residue	Details
A	ASN96

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	HIS147
A	HIS151

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	TYR168

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:8344894

Chain	Residue	Details
A	GLU183

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217

Chain	Residue	Details
A	MET170

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