4JDS
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
Summary for 4JDS
Entry DOI | 10.2210/pdb4jds/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (5 entities in total) |
Functional Keywords | setd7, sam, pf-5426, structural genomics consortium, sgc, methyltransferase, set domain, histone modification, transcription regulation, histone lysine methyltransferase, inhibitor, s-adenosyl-l-methionine, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q8WTS6 |
Total number of polymer chains | 4 |
Total formula weight | 122155.68 |
Authors | Dong, A.,Wu, H.,Zeng, H.,Park, H.,El Bakkouri, M.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2013-02-25, release date: 2013-03-27, Last modification date: 2023-09-20) |
Primary citation | Dong, A.,Wu, H.,Zeng, H.,El Bakkouri, M.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J. SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine to be published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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