4JDS

SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine

4JDS の概要

• エントリーDOI: 10.2210/pdb4jds/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (5 entities in total)
• 機能のキーワード: setd7, sam, pf-5426, structural genomics consortium, sgc, methyltransferase, set domain, histone modification, transcription regulation, histone lysine methyltransferase, inhibitor, s-adenosyl-l-methionine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8WTS6
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122155.68

構造登録者

Dong, A.,Wu, H.,Zeng, H.,Park, H.,El Bakkouri, M.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2013-02-25, 公開日: 2013-03-27, 最終更新日: 2023-09-20)

• 主引用文献: Dong, A.,Wu, H.,Zeng, H.,El Bakkouri, M.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.; SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine; to be published,

実験手法

X-RAY DIFFRACTION (1.7 Å)