4JBY

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78

Summary for 4JBY

• Entry DOI: 10.2210/pdb4jby/pdb
• Related: 1E2P 3F0T 3RDP 4IVP 4IVQ 4IVR 4JBX
• Descriptor: Thymidine kinase, 6-[(1Z)-3-fluoro-2-(hydroxymethyl)prop-1-en-1-yl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, SULFATE ION, ... (5 entities in total)
• Functional Keywords: dna synthesis, pet imaging tracer, atp binding, nucleotide binding, transferase
• Biological source: Human herpesvirus 1 (HHV-1)
• Total number of polymer chains: 2
• Total formula weight: 72815.36

Authors

Pernot, L.,Novakovic, I.,Westermaier, Y.,Perozzo, R.,Raic-Malic, S.,Scapozza, L. (deposition date: 2013-02-20, release date: 2013-03-06, Last modification date: 2023-09-20)

• Primary citation: Pernot, L.,Novakovic, I.,Perozzo, R.,Raic-Malic, S.,Scapozza, L.; New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)