3RDP
Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT
Summary for 3RDP
Entry DOI | 10.2210/pdb3rdp/pdb |
Related | 1E2H 1E2P 3F0T |
Descriptor | Thymidine kinase, SULFATE ION, 6-[(2R)-2-(fluoromethyl)-3-hydroxy-propyl]-1,5-dimethyl-pyrimidine-2,4-dione, ... (4 entities in total) |
Functional Keywords | transferase, thymidine kinase, dna-synthesis, pet tracer, atp-binding, dna synthesis, early protein, nucleotide-binding |
Biological source | Human herpesvirus 1 (HHV-1) |
Total number of polymer chains | 2 |
Total formula weight | 72306.83 |
Authors | Pernot, L.,Perozzo, R.,Westermaier, Y.,Martic, M.,Ametamey, S.,Scapozza, L. (deposition date: 2011-04-01, release date: 2011-08-03, Last modification date: 2023-11-01) |
Primary citation | Martic, M.,Pernot, L.,Westermaier, Y.,Perozzo, R.,Kraljevic, T.G.,Kristafor, S.,Raic-Malic, S.,Scapozza, L.,Ametamey, S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids, 30:293-315, 2011 Cited by PubMed: 21623543DOI: 10.1080/15257770.2011.581258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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