4J99
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.
Summary for 4J99
Entry DOI | 10.2210/pdb4j99/pdb |
Related | 2PSQ 2PVF 4J95 4J96 4J97 4J98 |
Descriptor | Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | bilobate protein kinase fold, receptor tyrosine kinase, atp binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 4 |
Total formula weight | 151096.22 |
Authors | Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2023-09-20) |
Primary citation | Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M. Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4:376-384, 2013 Cited by PubMed: 23871672DOI: 10.1016/j.celrep.2013.06.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8474 Å) |
Structure validation
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