4J99

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	ARG625
A	ARG649
A	TYR657
A	THR659

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ACP A 802

Chain	Residue
A	LYS517
A	VAL564
A	GLU565
A	ALA567
A	ASP626
A	ARG630
A	ASN631
A	LEU633
A	ASP644
A	HOH967
A	HOH968
A	HOH970
A	HOH972
A	GLY488
A	GLY490
A	ALA491
A	VAL495
A	ALA515

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 803

Chain	Residue
A	THR635
A	GLU636
A	ASN637
A	VAL639

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 801

Chain	Residue
B	ARG625
B	ARG649
B	TYR657
B	THR659
B	THR660
B	HOH932

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ACP B 802

Chain	Residue
B	GLY488
B	GLY490
B	ALA491
B	VAL495
B	ALA515
B	VAL564
B	GLU565
B	ALA567
B	ASN571
B	ASP626
B	ASN631
B	LEU633
B	ASP644
B	HOH930
B	HOH1013

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 803

Chain	Residue
A	THR729
A	ASN730
A	GLU731
B	ARG478
B	HOH931
B	HOH992

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 801

Chain	Residue
C	ARG625
C	ARG649
C	TYR657
C	THR659
C	THR660
C	HOH922

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ACP C 802

Chain	Residue
C	LEU487
C	GLY488
C	PHE492
C	VAL495
C	ALA515
C	LYS517
C	GLU565
C	ALA567
C	ASN631
C	LEU633
C	ASP644
C	MG803
C	HOH959
C	HOH985

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 803

Chain	Residue
C	ASN631
C	ASP644
C	ACP802

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 804

Chain	Residue
C	THR635
C	ASN637
C	VAL639

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 801

Chain	Residue
D	ARG625
D	ARG649
D	TYR657
D	THR659
D	HOH962

---

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ACP D 802

Chain	Residue
D	HOH945
D	HOH970
D	GLY490
D	ALA491
D	PHE492
D	ALA515
D	LYS517
D	VAL564
D	GLU565
D	ALA567
D	ASN571
D	ARG630
D	ASN631
D	LEU633
D	ASP644
D	MG803
D	MG804

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 803

Chain	Residue
D	ASN631
D	ASP644
D	ACP802

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 804

Chain	Residue
D	LYS517
D	GLU534
D	ASP644
D	GLY646
D	ACP802

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeavgidkdkpkeavt...VAVK

Chain	Residue	Details
A	LEU487-LYS517

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS622-VAL634

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"17803937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---