4J98

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.

Summary for 4J98

• Entry DOI: 10.2210/pdb4j98/pdb
• Related: 2PSQ 2PVF 4J95 4J96 4J97 4J99
• Descriptor: Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: fgf receptor, receptor tyrosine kinase, gain-of-function mutation, atp binding, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• Total number of polymer chains: 2
• Total formula weight: 75204.59

Authors

Huang, Z.,Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2023-09-20)

• Primary citation: Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M.; Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.; Cell Rep, 4:376-384, 2013; PubMed: 23871672; DOI: 10.1016/j.celrep.2013.06.025

Experimental method

X-RAY DIFFRACTION (2.3067 Å)