4J98

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 2	polymer	324	37109.5	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor
2	C, D, E, F, G (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	H (B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
4	I, J (A, B)	water	water		18.0	230	Chemie (HOH)

Sequence modifications

A, B: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	expression tag
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 491	engineered mutation
Gln 659	Lys 659	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74219.1
Non-Polymers*	Number of molecules	6
	Total formula weight	985.5
All*	Total formula weight	75204.6

*Water molecules are not included.