4J96

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.

Summary for 4J96

Entry DOI	10.2210/pdb4j96/pdb
Related	2PSQ 2PVF 4J95 4J97 4J98 4J99
Descriptor	Fibroblast growth factor receptor 2, SULFATE ION, CITRATE ANION, ... (6 entities in total)
Functional Keywords	kinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, atp binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	2
Total formula weight	75421.10
Authors	Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citation	Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M. Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4:376-384, 2013 Cited by PubMed: 23871672 DOI: 10.1016/j.celrep.2013.06.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2972 Å)

Structure validation