4J96

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 2	polymer	324	37112.6	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor
2	C, E, F (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	D, H (A, B)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
4	G (B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
5	I (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	J, K (A, B)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A, B: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	expression tag
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 491	engineered mutation
Met 659	Lys 659	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74225.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1195.9
All*	Total formula weight	75421.1

*Water molecules are not included.