4J8S

Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide

Summary for 4J8S

• Entry DOI: 10.2210/pdb4j8s/pdb
• Descriptor: CCR4-NOT transcription complex subunit 1, Tristetraprolin (3 entities in total)
• Functional Keywords: mif4g, protein-protein interaction, ttp, cytosol, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, P-body : A5YKK6; Nucleus : P26651
• Total number of polymer chains: 2
• Total formula weight: 25791.35

Authors

Frank, F.,Fabian, M.R.,Rouya, C.,Siddiqui, N.,Lai, W.S.,Karetnikov, A.,Blackshear, P.J.,Sonenberg, N.,Nagar, B. (deposition date: 2013-02-14, release date: 2013-05-08, Last modification date: 2024-02-28)

• Primary citation: Fabian, M.R.,Frank, F.,Rouya, C.,Siddiqui, N.,Lai, W.S.,Karetnikov, A.,Blackshear, P.J.,Nagar, B.,Sonenberg, N.; Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.; Nat.Struct.Mol.Biol., 20:735-739, 2013; PubMed: 23644599; DOI: 10.1038/nsmb.2572

Experimental method

X-RAY DIFFRACTION (1.55 Å)