4J51

Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04

4J51 の概要

• エントリーDOI: 10.2210/pdb4j51/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 22, 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid (3 entities in total)
• 機能のキーワード: hydrolase, tyrosine phosphatase, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q9Y2R2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77269.10

構造登録者

Liu, D.,He, Y.,Zhang, Z.-Y. (登録日: 2013-02-07, 公開日: 2013-07-24, 最終更新日: 2023-09-20)

• 主引用文献: He, Y.,Liu, S.,Menon, A.,Stanford, S.,Oppong, E.,Gunawan, A.M.,Wu, L.,Wu, D.J.,Barrios, A.M.,Bottini, N.,Cato, A.C.,Zhang, Z.Y.; A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.; J.Med.Chem., 56:4990-5008, 2013; PubMed: 23713581; DOI: 10.1021/jm400248c

実験手法

X-RAY DIFFRACTION (2.3 Å)