4J50
Crystal Structure of an Expanded RNA CAG Repeat
Summary for 4J50
Entry DOI | 10.2210/pdb4j50/pdb |
Descriptor | RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3'), PHOSPHATE ION (3 entities in total) |
Functional Keywords | a form rna, cag repeat expansion, polyq, gain of rna function, huntingtin disease, spinal-bulbar muscular atrophy, dentatorubral-pallidoluysian atrophy, spinocerebellar ataxia, rna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 12407.32 |
Authors | Park, H.,Disney, M.D. (deposition date: 2013-02-07, release date: 2013-02-20, Last modification date: 2024-02-28) |
Primary citation | Yildirim, I.,Park, H.,Disney, M.D.,Schatz, G.C. A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations. J.Am.Chem.Soc., 135:3528-3538, 2013 Cited by PubMed: 23441937DOI: 10.1021/ja3108627 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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