4J4Q

Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

Summary for 4J4Q

• Entry DOI: 10.2210/pdb4j4q/pdb
• Related PRD ID: PRD_900006
• Descriptor: Rhodopsin, Guanine nucleotide-binding protein G(t) subunit alpha-1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: g-protein coupled receptor, photoreceptor protein, receptor retinal protein, transducer, transmembrane, glycoprotein, lipoprotein, sensory transduction, signaling protein, galpha subunit, gtp-binding, myristate, nucleotide-binding, retinal binding, membrane
• Biological source: Bos taurus (bovine); More
• Total number of polymer chains: 2
• Total formula weight: 43060.99

Authors

Park, J.H.,Morizumi, T.,Li, Y.,Hong, J.E.,Pai, E.F.,Hofmann, K.P.,Choe, H.W.,Ernst, O.P. (deposition date: 2013-02-07, release date: 2013-10-30, Last modification date: 2024-10-16)

Primary citation

Park, J.H.,Morizumi, T.,Li, Y.,Hong, J.E.,Pai, E.F.,Hofmann, K.P.,Choe, H.W.,Ernst, O.P.
Opsin, a structural model for olfactory receptors?
Angew.Chem.Int.Ed.Engl., 52:11021-11024, 2013

PubMed Abstract: Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

PubMed: 24038729
DOI: 10.1002/anie.201302374

Experimental method

X-RAY DIFFRACTION (2.65 Å)