4ITS

Crystal structure of the catalytic domain of human Pus1 with MES in the active site

4ITS の概要

• エントリーDOI: 10.2210/pdb4its/pdb
• 関連するPDBエントリー: 4IQM 4J37
• 分子名称: tRNA pseudouridine synthase A, mitochondrial, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta sheet, isomerase, pseudouridine synthase, rna binding protein, rna modification, trna, pre-trna, steroid receptor rna activator, u2 snrna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Mitochondrion. Isoform 2: Nucleus: Q9Y606
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38529.85

構造登録者

Czudnochowski, N.,Finer-Moore, J.S.,Stroud, R.M. (登録日: 2013-01-18, 公開日: 2013-06-05, 最終更新日: 2013-10-23)

• 主引用文献: Czudnochowski, N.,Wang, A.L.,Finer-Moore, J.,Stroud, R.M.; In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.; J.Mol.Biol., 425:3875-3887, 2013; PubMed: 23707380; DOI: 10.1016/j.jmb.2013.05.014

実験手法

X-RAY DIFFRACTION (1.85 Å)