4ITP
Structure of human carbonic anhydrase II bound to a benzene sulfonamide
Summary for 4ITP
| Entry DOI | 10.2210/pdb4itp/pdb |
| Related | 4ITO |
| Descriptor | Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... (6 entities in total) |
| Functional Keywords | alpha beta fold, reversible hydration of carbon dioxide to bicarbonate and proton, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29841.02 |
| Authors | Biswas, S.,McKenna, R. (deposition date: 2013-01-18, release date: 2014-01-01, Last modification date: 2024-02-28) |
| Primary citation | Guzel-Akdemir, O.,Biswas, S.,Lastra, K.,McKenna, R.,Supuran, C.T. Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorg.Med.Chem., 21:6674-6680, 2013 Cited by PubMed: 24012377DOI: 10.1016/j.bmc.2013.08.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.697 Å) |
Structure validation
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