4ISW

Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP

Summary for 4ISW

Entry DOI	10.2210/pdb4isw/pdb
Related	3IHI 4E5O 4G9U 4IQB 4IQQ 4IRR
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	phosphoprotein, protein homodimer, deoxynucleotide biosynthesis, phosphorylation, transferase
Biological source	Caenorhabditis elegans (nematode)
Total number of polymer chains	2
Total formula weight	72488.13
Authors	Wilk, P.,Dowiercial, A.,Banaszak, K.,Jarmula, A.,Rypniewski, W.,Rode, W. (deposition date: 2013-01-17, release date: 2013-12-11, Last modification date: 2014-01-15)
Primary citation	Wilk, P.,Jarmua, A.,Ruman, T.,Banaszak, K.,Rypniewski, W.,Ciesla, J.,Dowiercia, A.,Rode, W. Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer. Bioorg.Chem., 52C:44-49, 2013 Cited by PubMed: 24321279 DOI: 10.1016/j.bioorg.2013.11.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.14 Å)

Structure validation