4ISW
Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP
Summary for 4ISW
Entry DOI | 10.2210/pdb4isw/pdb |
Related | 3IHI 4E5O 4G9U 4IQB 4IQQ 4IRR |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total) |
Functional Keywords | phosphoprotein, protein homodimer, deoxynucleotide biosynthesis, phosphorylation, transferase |
Biological source | Caenorhabditis elegans (nematode) |
Total number of polymer chains | 2 |
Total formula weight | 72488.13 |
Authors | Wilk, P.,Dowiercial, A.,Banaszak, K.,Jarmula, A.,Rypniewski, W.,Rode, W. (deposition date: 2013-01-17, release date: 2013-12-11, Last modification date: 2014-01-15) |
Primary citation | Wilk, P.,Jarmua, A.,Ruman, T.,Banaszak, K.,Rypniewski, W.,Ciesla, J.,Dowiercia, A.,Rode, W. Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer. Bioorg.Chem., 52C:44-49, 2013 Cited by PubMed: 24321279DOI: 10.1016/j.bioorg.2013.11.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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