4ISW
Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP A 401 |
| Chain | Residue |
| A | CYS197 |
| A | TYR260 |
| B | ARG177 |
| B | ARG178 |
| A | GLN216 |
| A | ARG217 |
| A | SER218 |
| A | GLY219 |
| A | ASP220 |
| A | GLY224 |
| A | ASN228 |
| A | HIS258 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP B 401 |
| Chain | Residue |
| A | ARG177 |
| A | ARG178 |
| B | ARG51 |
| B | CYS197 |
| B | GLN216 |
| B | ARG217 |
| B | SER218 |
| B | GLY219 |
| B | ASP220 |
| B | GLY224 |
| B | ASN228 |
| B | HIS258 |
| B | TYR260 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlgqmv.....LpPCHtmcQFyV |
| Chain | Residue | Details |
| A | ARG177-VAL205 |
