4ISW
Crystal Structure of Phosphorylated C.elegans Thymidylate Synthase in Complex with dUMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UMP A 401 |
Chain | Residue |
A | CYS197 |
A | TYR260 |
B | ARG177 |
B | ARG178 |
A | GLN216 |
A | ARG217 |
A | SER218 |
A | GLY219 |
A | ASP220 |
A | GLY224 |
A | ASN228 |
A | HIS258 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP B 401 |
Chain | Residue |
A | ARG177 |
A | ARG178 |
B | ARG51 |
B | CYS197 |
B | GLN216 |
B | ARG217 |
B | SER218 |
B | GLY219 |
B | ASP220 |
B | GLY224 |
B | ASN228 |
B | HIS258 |
B | TYR260 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlgqmv.....LpPCHtmcQFyV |
Chain | Residue | Details |
A | ARG177-VAL205 |