4ISI
Structure of FACTOR VIIA in complex with the inhibitor (6S)-N-(4-CARBAMIMIDOYLBENZYL)-1-CHLORO-3-(CYCLOBUTYLAMINO)-8,8-DIETHYL-4-OXO-4,6,7,8-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE
Summary for 4ISI
Entry DOI | 10.2210/pdb4isi/pdb |
Related | 4ISH |
Descriptor | Factor VII heavy chain, Factor VII light chain, (6S)-N-(4-carbamimidoylbenzyl)-1-chloro-3-(cyclobutylamino)-8,8-diethyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide, ... (5 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 34645.16 |
Authors | |
Primary citation | Zhang, X.,Glunz, P.W.,Jiang, W.,Schmitt, A.,Newman, M.,Barbera, F.A.,Bozarth, J.M.,Rendina, A.R.,Wei, A.,Wen, X.,Rossi, K.A.,Luettgen, J.M.,Wong, P.C.,Knabb, R.M.,Wexler, R.R.,Scott Priestley, E. Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Bioorg.Med.Chem.Lett., 23:1604-1607, 2013 Cited by PubMed: 23416003DOI: 10.1016/j.bmcl.2013.01.094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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