4IRU

Crystal Structure of lepB GAP core in a transition state mimetic complex with Rab1A and ALF3

4IRU の概要

• エントリーDOI: 10.2210/pdb4iru/pdb
• 分子名称: LepB, Ras-related protein Rab-1A, ACETATE ION, ... (9 entities in total)
• 機能のキーワード: arginine finger, glutamate finger, p-loop motif, nucleotide binding, intrinsic gtpase activity, gtp hydrolysis, gtp hydrolysis activator, gtpase activating protein (gap), protein transport, hydrolase-hydrolase complex, hydrolase/hydrolase
• 由来する生物種: Legionella pneumophila; 詳細
• 細胞内の位置: Golgi apparatus: P62820
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 168608.75

構造登録者

Mishra, A.K.,Delcampo, C.M.,Collins, R.E.,Roy, C.R.,Lambright, D.G. (登録日: 2013-01-15, 公開日: 2013-07-10, 最終更新日: 2013-09-04)

• 主引用文献: Mishra, A.K.,Del Campo, C.M.,Collins, R.E.,Roy, C.R.,Lambright, D.G.; The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism.; J.Biol.Chem., 288:24000-24011, 2013; PubMed: 23821544; DOI: 10.1074/jbc.M113.470625

実験手法

X-RAY DIFFRACTION (3.2 Å)