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4IR3

Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-amino-1-(pyrimidin-2-yl)indolizin-3-yl]ethanone (GSK2833282A)

Summary for 4IR3
Entry DOI10.2210/pdb4ir3/pdb
Related4IR4 4IR5 4IR6 4RVR
DescriptorBromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, GLYCEROL, ... (5 entities in total)
Functional Keywordssgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4
Biological sourceHomo sapiens (human)
Cellular locationNucleus : Q9UIF8
Total number of polymer chains1
Total formula weight14241.32
Authors
Primary citationChen, P.,Chaikuad, A.,Bamborough, P.,Bantscheff, M.,Bountra, C.,Chung, C.W.,Fedorov, O.,Grandi, P.,Jung, D.,Lesniak, R.,Lindon, M.,Muller, S.,Philpott, M.,Prinjha, R.,Rogers, C.,Selenski, C.,Tallant, C.,Werner, T.,Willson, T.M.,Knapp, S.,Drewry, D.H.
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59:1410-1424, 2016
Cited by
PubMed: 25799074
DOI: 10.1021/acs.jmedchem.5b00209
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

221051

数据于2024-06-12公开中

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