4IQY

Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2

Summary for 4IQY

Entry DOI	10.2210/pdb4iqy/pdb
Descriptor	O-acetyl-ADP-ribose deacetylase MACROD2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	macrodomain, hydrolase, adp-ribose binding, adp-ribosylation, nuclear/cytoplasmic
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	55307.62
Authors	Jankevicius, G.,Hassler, M.,Golia, B.,Rybin, V.,Zacharias, M.,Timinszky, G.,Ladurner, A.G. (deposition date: 2013-01-14, release date: 2013-03-06, Last modification date: 2023-09-20)
Primary citation	Jankevicius, G.,Hassler, M.,Golia, B.,Rybin, V.,Zacharias, M.,Timinszky, G.,Ladurner, A.G. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat.Struct.Mol.Biol., 20:508-514, 2013 Cited by PubMed: 23474712 DOI: 10.1038/nsmb.2523 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation