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4IQU

Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid

Summary for 4IQU
Entry DOI10.2210/pdb4iqu/pdb
Related4IQT 4IQV 4IQW
DescriptorDNA nucleotidylexotransferase, SODIUM ION, (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, ... (4 entities in total)
Functional Keywordsterminal transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (mouse)
More
Cellular locationIsoform TDT-S: Nucleus. Isoform TDT-L: Cytoplasm. Nucleus : P09838
Total number of polymer chains1
Total formula weight46056.29
Authors
Gouge, J.,Delarue, M. (deposition date: 2013-01-13, release date: 2013-09-04, Last modification date: 2024-03-13)
Primary citationCosti, R.,Cuzzucoli Crucitti, G.,Pescatori, L.,Messore, A.,Scipione, L.,Tortorella, S.,Amoroso, A.,Crespan, E.,Campiglia, P.,Maresca, B.,Porta, A.,Granata, I.,Novellino, E.,Gouge, J.,Delarue, M.,Maga, G.,Di Santo, R.
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J.Med.Chem., 56:7431-7441, 2013
Cited by
PubMed: 23968551
DOI: 10.1021/jm4010187
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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