5NOO

Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex

Replaces:  4IQQ

Summary for 5NOO

• Entry DOI: 10.2210/pdb5noo/pdb
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (4 entities in total)
• Functional Keywords: transferase, enzyme, nematode, complex
• Biological source: Caenorhabditis elegans
• Total number of polymer chains: 4
• Total formula weight: 146490.29

Authors

Wilk, P.,Jarmula, A.,Maj, P.,Dowiercial, A.,Banaszak, K.,Rypniewski, W.,Rode, W. (deposition date: 2017-04-12, release date: 2017-05-03, Last modification date: 2024-01-17)

• Primary citation: Jarmua, A.,Wilk, P.,Maj, P.,Ludwiczak, J.,Dowiercia, A.,Banaszak, K.,Rypniewski, W.,Ciesla, J.,Dabrowska, M.,Fraczyk, T.,Bronowska, A.K.,Jakowiecki, J.,Filipek, S.,Rode, W.; Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.; J. Mol. Graph. Model., 77:33-50, 2017; PubMed: 28826032; DOI: 10.1016/j.jmgm.2017.08.008

Experimental method

X-RAY DIFFRACTION (2.9 Å)