5NOO
Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex
Replaces: 4IQQFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006235 | biological_process | dTTP biosynthetic process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0009165 | biological_process | nucleotide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0032259 | biological_process | methylation |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006235 | biological_process | dTTP biosynthetic process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009165 | biological_process | nucleotide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue UMP A 401 |
| Chain | Residue |
| A | ARG51 |
| A | TYR260 |
| A | D16402 |
| B | ARG177 |
| B | ARG178 |
| A | CYS197 |
| A | GLN216 |
| A | ARG217 |
| A | SER218 |
| A | ASP220 |
| A | GLY224 |
| A | ASN228 |
| A | HIS258 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue D16 A 402 |
| Chain | Residue |
| A | TYR82 |
| A | ILE110 |
| A | ASP220 |
| A | LEU223 |
| A | GLY224 |
| A | PHE227 |
| A | TYR260 |
| A | UMP401 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue UMP B 401 |
| Chain | Residue |
| A | ARG177 |
| B | ARG51 |
| B | CYS197 |
| B | HIS198 |
| B | GLN216 |
| B | ARG217 |
| B | SER218 |
| B | ASP220 |
| B | GLY224 |
| B | ASN228 |
| B | HIS258 |
| B | TYR260 |
| B | D16402 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue D16 B 402 |
| Chain | Residue |
| B | TYR82 |
| B | ILE110 |
| B | ASP220 |
| B | LEU223 |
| B | GLY224 |
| B | PHE227 |
| B | TYR260 |
| B | UMP401 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue UMP C 401 |
| Chain | Residue |
| C | CYS197 |
| C | GLN216 |
| C | ARG217 |
| C | SER218 |
| C | GLY219 |
| C | ASP220 |
| C | GLY224 |
| C | ASN228 |
| C | HIS258 |
| C | TYR260 |
| C | D16402 |
| D | ARG177 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue D16 C 402 |
| Chain | Residue |
| C | ARG80 |
| C | TYR82 |
| C | ASP220 |
| C | LEU223 |
| C | GLY224 |
| C | PHE227 |
| C | TYR260 |
| C | UMP401 |
| C | HOH505 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue UMP D 401 |
| Chain | Residue |
| C | ARG177 |
| C | ARG178 |
| D | CYS197 |
| D | HIS198 |
| D | GLN216 |
| D | ARG217 |
| D | SER218 |
| D | GLY219 |
| D | ASP220 |
| D | GLY224 |
| D | ASN228 |
| D | HIS258 |
| D | TYR260 |
| D | D16402 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue D16 D 402 |
| Chain | Residue |
| D | ARG80 |
| D | VAL81 |
| D | TYR82 |
| D | ILE110 |
| D | ASP220 |
| D | LEU223 |
| D | GLY224 |
| D | PHE227 |
| D | TYR260 |
| D | UMP401 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlgqmv.....LpPCHtmcQFyV |
| Chain | Residue | Details |
| A | ARG177-VAL205 |
