4IJL

Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A

4IJL の概要

• エントリーDOI: 10.2210/pdb4ijl/pdb
• 関連するPDBエントリー: 4IJH
• 分子名称: Replication protein A 70 kDa DNA-binding subunit, {[5-(3-chloro-1-benzothiophen-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid (3 entities in total)
• 機能のキーワード: ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P27694
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14301.51

構造登録者

Feldkamp, M.D.,Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Fesik, S.W.,Chazin, W.J. (登録日: 2012-12-21, 公開日: 2013-08-14, 最終更新日: 2023-09-20)

• 主引用文献: Patrone, J.D.,Kennedy, J.P.,Frank, A.O.,Feldkamp, M.D.,Vangamudi, B.,Pelz, N.F.,Rossanese, O.W.,Waterson, A.G.,Chazin, W.J.,Fesik, S.W.; Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.; ACS MED.CHEM.LETT., 4:601-605, 2013; PubMed: 23914285; DOI: 10.1021/ml400032y

実験手法

X-RAY DIFFRACTION (1.7 Å)