4IIR
Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain
Summary for 4IIR
Entry DOI | 10.2210/pdb4iir/pdb |
Related | 4IAN 4IFC 4IJP |
Descriptor | Serine/threonine-protein kinase PRP4 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13523 |
Total number of polymer chains | 2 |
Total formula weight | 85287.89 |
Authors | Mechin, I.,Haas, K.,Chen, X.,Zhang, Y.,McLean, L. (deposition date: 2012-12-20, release date: 2013-08-28, Last modification date: 2017-11-15) |
Primary citation | Gao, Q.,Mechin, I.,Kothari, N.,Guo, Z.,Deng, G.,Haas, K.,McManus, J.,Hoffmann, D.,Wang, A.,Wiederschain, D.,Rocnik, J.,Czechtizky, W.,Chen, X.,McLean, L.,Arlt, H.,Harper, D.,Liu, F.,Majid, T.,Patel, V.,Lengauer, C.,Garcia-Echeverria, C.,Zhang, B.,Cheng, H.,Dorsch, M.,Huang, S.M. Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288:30125-30138, 2013 Cited by PubMed: 24003220DOI: 10.1074/jbc.M113.473348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report