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4IIR

Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
A0045292biological_processmRNA cis splicing, via spliceosome
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
B0045292biological_processmRNA cis splicing, via spliceosome
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ANP A 1101
ChainResidue
ATHR693
AASN773
AASP819
AASN820
ALEU822
AASP834
AMG1103
AHOH1211
AHOH1276
AHOH1327
AHOH1388
ASER699
AVAL701
AALA715
ALYS717
ALEU751
APHE767
AGLU768
ALEU770

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1102
ChainResidue
APTR849
AARG853
AARG856
AHOH1248
AHOH1285
AHOH1305

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG A 1103
ChainResidue
AANP1101
AHOH1331

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ANP B 1101
ChainResidue
BTHR693
BSER699
BVAL701
BALA715
BLYS717
BLEU751
BPHE767
BGLU768
BLEU770
BASN773
BASP819
BASN820
BLEU822
BASP834

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 1102
ChainResidue
AARG709
BARG686
BARG709
BHOH1314
BHOH1322
BHOH1377

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1103
ChainResidue
BPTR849
BARG853
BARG856
BHOH1228

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1104
ChainResidue
BLYS804
BARG808
BHOH1258
BHOH1289

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV
ChainResidueDetails
AILE811-VAL823

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP815
BASP815

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ATHR693
ALYS717
BTHR693
BLYS717

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS717
BLYS717

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
APTR849
BPTR849

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RKH1
ChainResidueDetails
ASER852
BSER852

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS659
BLYS659

224201

PDB entries from 2024-08-28

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