4IIR
Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANP A 1101 |
| Chain | Residue |
| A | THR693 |
| A | ASN773 |
| A | ASP819 |
| A | ASN820 |
| A | LEU822 |
| A | ASP834 |
| A | MG1103 |
| A | HOH1211 |
| A | HOH1276 |
| A | HOH1327 |
| A | HOH1388 |
| A | SER699 |
| A | VAL701 |
| A | ALA715 |
| A | LYS717 |
| A | LEU751 |
| A | PHE767 |
| A | GLU768 |
| A | LEU770 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1102 |
| Chain | Residue |
| A | PTR849 |
| A | ARG853 |
| A | ARG856 |
| A | HOH1248 |
| A | HOH1285 |
| A | HOH1305 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 1103 |
| Chain | Residue |
| A | ANP1101 |
| A | HOH1331 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ANP B 1101 |
| Chain | Residue |
| B | THR693 |
| B | SER699 |
| B | VAL701 |
| B | ALA715 |
| B | LYS717 |
| B | LEU751 |
| B | PHE767 |
| B | GLU768 |
| B | LEU770 |
| B | ASN773 |
| B | ASP819 |
| B | ASN820 |
| B | LEU822 |
| B | ASP834 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1102 |
| Chain | Residue |
| A | ARG709 |
| B | ARG686 |
| B | ARG709 |
| B | HOH1314 |
| B | HOH1322 |
| B | HOH1377 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1103 |
| Chain | Residue |
| B | PTR849 |
| B | ARG853 |
| B | ARG856 |
| B | HOH1228 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1104 |
| Chain | Residue |
| B | LYS804 |
| B | ARG808 |
| B | HOH1258 |
| B | HOH1289 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV |
| Chain | Residue | Details |
| A | ILE811-VAL823 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RKH1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
