4IFY
HIV-1 reverse transcriptase with bound fragment at the Knuckles site
Summary for 4IFY
Entry DOI | 10.2210/pdb4ify/pdb |
Related | 4I7G 4ICL 4ID5 4IDK 4IFV 4IG0 4IG3 |
Descriptor | REVERSE TRANSCRIPTASE/RIBONUCLEASE H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total) |
Functional Keywords | rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 115917.78 |
Authors | Bauman, J.D.,Patel, D.,Arnold, E. (deposition date: 2012-12-15, release date: 2013-02-06, Last modification date: 2024-02-28) |
Primary citation | Bauman, J.D.,Patel, D.,Dharia, C.,Fromer, M.W.,Ahmed, S.,Frenkel, Y.,Vijayan, R.S.,Eck, J.T.,Ho, W.C.,Das, K.,Shatkin, A.J.,Arnold, E. Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening. J.Med.Chem., 56:2738-2746, 2013 Cited by PubMed: 23342998DOI: 10.1021/jm301271j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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