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4IDK

HIV-1 reverse transcriptase with bound fragment at the 428 site

Summary for 4IDK
Entry DOI10.2210/pdb4idk/pdb
Related4I7G 4ICL 4ID5 4IFV 4IFY 4IG0 4IG3
DescriptorReverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total)
Functional Keywordsrna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains2
Total formula weight115932.83
Authors
Bauman, J.D.,Patel, D.,Arnold, E. (deposition date: 2012-12-12, release date: 2013-02-06, Last modification date: 2024-02-28)
Primary citationBauman, J.D.,Patel, D.,Dharia, C.,Fromer, M.W.,Ahmed, S.,Frenkel, Y.,Vijayan, R.S.,Eck, J.T.,Ho, W.C.,Das, K.,Shatkin, A.J.,Arnold, E.
Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56:2738-2746, 2013
Cited by
PubMed: 23342998
DOI: 10.1021/jm301271j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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