4IEH

Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions

4IEH の概要

• エントリーDOI: 10.2210/pdb4ieh/pdb
• 分子名称: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide (3 entities in total)
• 機能のキーワード: protein-protein interaction, alpha helical, pro-apoptosis, cytochrome c release, caspase activation, bim, bak, bad, puma, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion outer membrane ; Single-pass membrane protein : P10415
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20514.32

構造登録者

Xie, X.,Kulathila, R. (登録日: 2012-12-13, 公開日: 2013-07-10, 最終更新日: 2024-02-28)

• 主引用文献: Toure, B.B.,Miller-Moslin, K.,Yusuff, N.,Perez, L.,Dore, M.,Joud, C.,Michael, W.,DiPietro, L.,van der Plas, S.,McEwan, M.,Lenoir, F.,Hoe, M.,Karki, R.,Springer, C.,Sullivan, J.,Levine, K.,Fiorilla, C.,Xie, X.,Kulathila, R.,Herlihy, K.,Porter, D.,Visser, M.; The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.; ACS Med Chem Lett, 4:186-190, 2013; PubMed: 24900652; DOI: 10.1021/ml300321d

実験手法

X-RAY DIFFRACTION (2.1 Å)