4ID1

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor

4ID1 の概要

• エントリーDOI: 10.2210/pdb4id1/pdb
• 関連するPDBエントリー: 1ITG
• 分子名称: Gag-Pol polyprotein, (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv integrase, ccd, dde motif, dimer interface, allosteric inhibitor, quinoline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18846.12

構造登録者

Feng, L.,Kvaratskhelia, M. (登録日: 2012-12-11, 公開日: 2013-05-01, 最終更新日: 2023-09-20)

• 主引用文献: Jurado, K.A.,Wang, H.,Slaughter, A.,Feng, L.,Kessl, J.J.,Koh, Y.,Wang, W.,Ballandras-Colas, A.,Patel, P.A.,Fuchs, J.R.,Kvaratskhelia, M.,Engelman, A.; Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.; Proc.Natl.Acad.Sci.USA, 110:8690-8695, 2013; PubMed: 23610442; DOI: 10.1073/pnas.1300703110

実験手法

X-RAY DIFFRACTION (1.87 Å)