4I9I
Crystal structure of tankyrase 1 with compound 4
Summary for 4I9I
Entry DOI | 10.2210/pdb4i9i/pdb |
Related | 4DVI |
Descriptor | Tankyrase-1, ZINC ION, N-(2-methoxyphenyl)-4-{[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino}benzamide, ... (4 entities in total) |
Functional Keywords | tankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 4 |
Total formula weight | 102196.83 |
Authors | Huang, X. (deposition date: 2012-12-05, release date: 2013-02-06, Last modification date: 2013-05-22) |
Primary citation | Bregman, H.,Gunaydin, H.,Gu, Y.,Schneider, S.,Wilson, C.,DiMauro, E.F.,Huang, X. Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket. J.Med.Chem., 56:1341-1345, 2013 Cited by PubMed: 23316926DOI: 10.1021/jm301607v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report