4I9I

Crystal structure of tankyrase 1 with compound 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1401

Chain	Residue
A	CYS1234
A	HIS1237
A	CYS1242
A	CYS1245

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 1DY A 1402

Chain	Residue
A	PHE1197
A	ASP1198
A	HIS1201
A	TYR1213
A	PHE1214
A	ALA1215
A	LYS1220
A	SER1221
A	TYR1224
A	GLU1291
A	HIS1184
A	GLY1185
A	PHE1188
A	ALA1191
A	GLY1196

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1401

Chain	Residue
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 1DY B 1402

Chain	Residue
B	HIS1184
B	GLY1185
B	PHE1188
B	ALA1191
B	GLY1196
B	PHE1197
B	ASP1198
B	HIS1201
B	TYR1213
B	PHE1214
B	ALA1215
B	LYS1220
B	SER1221
B	TYR1224
B	GLU1291

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1401

Chain	Residue
C	CYS1234
C	HIS1237
C	CYS1242
C	CYS1245

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 1DY C 1402

Chain	Residue
C	HIS1184
C	GLY1185
C	PHE1188
C	ILE1192
C	GLY1196
C	PHE1197
C	ASP1198
C	HIS1201
C	ILE1212
C	TYR1213
C	PHE1214
C	ALA1215
C	SER1221
C	TYR1224
C	GLU1291

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1401

Chain	Residue
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1DY D 1402

Chain	Residue
D	HIS1184
D	GLY1185
D	PHE1188
D	ALA1191
D	GLY1196
D	PHE1197
D	ASP1198
D	HIS1201
D	ILE1212
D	TYR1213
D	PHE1214
D	ALA1215
D	SER1221
D	TYR1224
D	GLU1291
D	HOH1522

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E

Chain	Residue	Details
A	CYS1234
C	HIS1237
C	CYS1242
C	CYS1245
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245
A	HIS1237
A	CYS1242
A	CYS1245
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245
C	CYS1234

---