4I80
Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics
Summary for 4I80
Entry DOI | 10.2210/pdb4i80/pdb |
Related | 3U84 3U85 3U88 |
Related PRD ID | PRD_000967 |
Descriptor | Menin, macrocyclic peptidomimetic (2 entities in total) |
Functional Keywords | menin, men1, mll, macrocyclic peptidomimetic, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O00255 |
Total number of polymer chains | 2 |
Total formula weight | 62188.62 |
Authors | |
Primary citation | Zhou, H.,Liu, L.,Huang, J.,Bernard, D.,Karatas, H.,Navarro, A.,Lei, M.,Wang, S. Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction. J.Med.Chem., 56:1113-1123, 2013 Cited by PubMed: 23244744DOI: 10.1021/jm3015298 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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