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4I80

Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000165biological_processMAPK cascade
A0000400molecular_functionfour-way junction DNA binding
A0000403molecular_functionY-form DNA binding
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000976molecular_functiontranscription cis-regulatory region binding
A0001933biological_processnegative regulation of protein phosphorylation
A0002076biological_processosteoblast development
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003690molecular_functiondouble-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006357biological_processregulation of transcription by RNA polymerase II
A0006974biological_processDNA damage response
A0008285biological_processnegative regulation of cell population proliferation
A0009411biological_processresponse to UV
A0010332biological_processresponse to gamma radiation
A0016363cellular_componentnuclear matrix
A0017053cellular_componenttranscription repressor complex
A0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
A0030674molecular_functionprotein-macromolecule adaptor activity
A0032154cellular_componentcleavage furrow
A0032991cellular_componentprotein-containing complex
A0035097cellular_componenthistone methyltransferase complex
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0044665cellular_componentMLL1/2 complex
A0045064biological_processT-helper 2 cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
A0045786biological_processnegative regulation of cell cycle
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046329biological_processnegative regulation of JNK cascade
A0051219molecular_functionphosphoprotein binding
A0070412molecular_functionR-SMAD binding
A0071339cellular_componentMLL1 complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
AGLU547

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER543

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR594

227344

PDB entries from 2024-11-13

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