4I7Y
Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II
Summary for 4I7Y
Entry DOI | 10.2210/pdb4i7y/pdb |
Related | 3QLP 4DIH 4DII |
Related PRD ID | PRD_000020 |
Descriptor | Prothrombin, DNA (27-MER), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (7 entities in total) |
Functional Keywords | protein-dna complex, serine protease, blood coagulation, aptamer, hydrolase-hydrolase inhibitor-dna complex, serine protease fold, dna aptamer, blood, g-quadruplex, duplex-quadruplex junction, hydrolase/hydrolase inhibitor/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 43060.37 |
Authors | Pica, A.,Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (deposition date: 2012-12-01, release date: 2013-10-16, Last modification date: 2024-10-09) |
Primary citation | Russo Krauss, I.,Pica, A.,Merlino, A.,Mazzarella, L.,Sica, F. Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer. Acta Crystallogr.,Sect.D, 69:2403-2411, 2013 Cited by PubMed: 24311581DOI: 10.1107/S0907444913022269 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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