4I7H
Structural basis for peroxide sensing and gene regulation by PerR from Streptococcus pyogenes
Summary for 4I7H
Entry DOI | 10.2210/pdb4i7h/pdb |
Descriptor | peroxide stress sensing regulator, NICKEL (II) ION, ZINC ION, ... (4 entities in total) |
Functional Keywords | winged helix-turn-helix motif, oxidative stress sensing, metal homeostasis, dna, transcription |
Biological source | Streptococcus pyogenes |
Total number of polymer chains | 2 |
Total formula weight | 38046.94 |
Authors | Kumaraswami, M. (deposition date: 2012-11-30, release date: 2013-05-08, Last modification date: 2024-02-28) |
Primary citation | Makthal, N.,Rastegari, S.,Sanson, M.,Ma, Z.,Olsen, R.J.,Helmann, J.D.,Musser, J.M.,Kumaraswami, M. Crystal Structure of Peroxide Stress Regulator from Streptococcus pyogenes Provides Functional Insights into the Mechanism of Oxidative Stress Sensing. J.Biol.Chem., 288:18311-18324, 2013 Cited by PubMed: 23645680DOI: 10.1074/jbc.M113.456590 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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